NFATc3-dependent loss of Ito gradient across the left ventricular wall during chronic β adrenergic stimulation
نویسندگان
چکیده
منابع مشابه
Differential calcineurin/NFATc3 activity contributes to the Ito transmural gradient in the mouse heart.
Kv4 channels are differentially expressed across the mouse left ventricular free wall. Accordingly, the transient outward K+ current (Ito), which is produced by Kv4 channels, is greater in left ventricular epicardial (EPI) than in endocardial (ENDO) cells. However, the mechanisms underlying heterogeneous Kv4 expression in the heart are unclear. Here, we tested the hypothesis that differential [...
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ژورنال
عنوان ژورنال: Journal of Molecular and Cellular Cardiology
سال: 2009
ISSN: 0022-2828
DOI: 10.1016/j.yjmcc.2008.10.016